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GHR binding induces receptor dimerisation and activation of the associated Janus kinase 2 (JAK2), triggering a phosphorylation cascade that activates Signal Transducer and Activator of Transcription 5 (STAT5) the primary transcriptional mediator of GHs genomic effects, including IGF-1 gene expression

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For individuals specifically seeking to avoid IGF-1 elevation and glucose metabolism effects, AOD-9604s mechanism offers distinct advantages